Technology Process of rac-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(1,2,3,4-tetrahydroquinolin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide
There total 5 articles about rac-8-[(2,6-difluorobenzyl)oxy]-2-methyl-N-(1,2,3,4-tetrahydroquinolin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a] pyridine-3-carboxylic acid;
With
4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
3(R,S)-amino-1,2,3,4-tetrahydroquinoline;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ethanol / 24 h / Molecular sieve; Reflux
2.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C
3.2: 20 °C
With
4-methyl-morpholine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C
2.2: 20 °C
With
4-methyl-morpholine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
