(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

Base Information

Chemical Name:(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one
CAS No.:1416038-38-4
Molecular Formula:C₂₄H₂₁Cl₂NO₃
Molecular Weight:442.342
Hs Code.:

Synonyms:(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

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Chemical Property of (3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

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Technology Process of (3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

There total 7 articles about (3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1416038-36-2
N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-N-(methoxymethyl)-2-(3-methoxyphenyl)propanamide

: 1416038-38-4
(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

Guidance literature:: With C₃₉H₄₅N₂O₂⁽¹⁺⁾*I^(1-); potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 20 - 50 ℃; for 48h; Inert atmosphere;
DOI:10.1002/hlca.201200477

Reference yield:

: 1416038-36-2
N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-N-(methoxymethyl)-2-(3-methoxyphenyl)propanamide

: 1416038-39-5
(3S)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

: 1416038-38-4
(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

Guidance literature:: With (S,S)-1,3-bis(2,2-dimethyl-1-naphthylpropyl)imidazolium iodide; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 50 ℃; for 48h; Overall yield = 85 %; Inert atmosphere;
DOI:10.1002/hlca.201200477

Reference yield:

: 1798-09-0
m-methoxyphenylacetic acid

: 1416038-38-4
(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / 16 h / -78 - 20 °C

2.1: thionyl chloride / 8 h / Reflux

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

4.2: 0 - 20 °C

5.1: C₃₉H₄₅N₂O₂⁽¹⁺⁾*I^(1-); bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium tert-butylate / toluene / 48 h / 20 - 50 °C / Inert atmosphere

With thionyl chloride; C₃₉H₄₅N₂O₂⁽¹⁺⁾*I^(1-); potassium tert-butylate; sodium hydride; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/hlca.201200477