(±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride

Base Information

• Chemical Name: (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride
• CAS No.: 1017390-62-3
• Molecular Formula: C₁₆H₁₄Cl₂O₂
• Molecular Weight: 309.192
• Mol file: 1017390-62-3.mol

Synonyms:(±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride

Chemical Property of (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride

There total 3 articles about (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoic acid (1017216-71-5) → (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride (1017390-62-3)

Guidance literature:

With thionyl chloride; In toluene; at 80 ℃; for 16h;

DOI:10.1039/c4ob02526a

Reference yield:

m-methoxyphenylacetic acid (1798-09-0) → (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride (1017390-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / 16 h / -78 - 20 °C

2: thionyl chloride / 8 h / Reflux

With thionyl chloride; lithium diisopropyl amide;

DOI:10.1002/hlca.201200477

Reference yield:

1-bromomethyl-3-chlorobenzene (766-80-3) → (±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoyl chloride (1017390-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / 16 h / -78 - 20 °C

2: thionyl chloride / 8 h / Reflux

With thionyl chloride; lithium diisopropyl amide;

DOI:10.1002/hlca.201200477

upstream raw materials:

m-methoxyphenylacetic acid

1-bromomethyl-3-chlorobenzene

(±)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanoic acid

Downstream raw materials:

N-(2-bromo-5-chlorophenyl)-3-(3-chlorophenyl)-2-(3-methoxyphenyl)propanamide

(3S)-1-[(benzyloxy)methyl]-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-3-(3-methoxyphenyl)-2H-indol-2-one

(3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-1-(methoxymethyl)-3-(3-methoxyphenyl)-2H-indol-2-one