(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

Base Information

Chemical Name:(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol
CAS No.:1380698-30-5
Molecular Formula:C₁₃H₁₈O₄
Molecular Weight:238.284
Hs Code.:

Synonyms:(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

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Chemical Property of (2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

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Technology Process of (2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

There total 8 articles about (2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380698-28-1
ethyl 1-(2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-{[(methyloxy)methyl]oxy}phenyl)cyclopropanecarboxylate

: 1380698-30-5
(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: C₁₉H₃₂O₄Si

: 1380698-30-5
(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

Guidance literature:: C₁₉H₃₂O₄Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; In tetrahydrofuran;

Reference yield:

: 81245-32-1
(3-(methoxymethoxy)phenyl)methanol

: 1380698-30-5
(2-[1-(hydroxymethyl)cyclopropyl]-3-{[(methyloxy)methyl]oxy}phenyl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 20 °C

2.1: n-butyllithium / hexane / 2 h / 20 °C

2.2: -78 °C

3.1: toluene / 1.5 h / 90 °C

4.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 4.1: Corey-Chaykovsky cyclopropanation reaction;