(R)--O-mesylacetamidoxime

Base Information

• Chemical Name: (R)--O-mesylacetamidoxime
• CAS No.: 152120-34-8
• Molecular Formula: C₁₄H₁₉N₃O₆S
• Molecular Weight: 357.387
• Mol file: 152120-34-8.mol

Synonyms:(R)--O-mesylacetamidoxime

Chemical Property of (R)--O-mesylacetamidoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)--O-mesylacetamidoxime

There total 3 articles about (R)--O-mesylacetamidoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanesulfonyl chloride (124-63-0) + (R)-acetamidoxime (152120-32-6) → (R)--O-mesylacetamidoxime (152120-34-8)

Guidance literature:

With pyridine; at -25 - 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)81296-5

Reference yield:

(R)-amino-phenyl-acetic acid ethyl ester (39251-40-6) → (R)--O-mesylacetamidoxime (152120-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / hydroxybenzotriazole, dicyclohexylcarbodiimide (DCC) / dimethylformamide / 1.) 0 deg C, 2 h 2.) rt, 2 h

2: 95 percent / NH₂OH*HCl, soda / ethanol; H₂O / 1.) 35 deg C, 1 h 2.) rt, 5 d

3: 91 percent / pyridine / 0.5 h / -25 - 0 °C

With pyridine; hydroxylamine hydrochloride; sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)81296-5

Reference yield:

(R)-acetonitrile (152120-30-4) → (R)--O-mesylacetamidoxime (152120-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NH₂OH*HCl, soda / ethanol; H₂O / 1.) 35 deg C, 1 h 2.) rt, 5 d

2: 91 percent / pyridine / 0.5 h / -25 - 0 °C

With pyridine; hydroxylamine hydrochloride; sodium carbonate; In ethanol; water;

DOI:10.1016/S0040-4020(01)81296-5

upstream raw materials:

methanesulfonyl chloride

(R)-acetamidoxime

(R)-amino-phenyl-acetic acid ethyl ester

(R)-acetonitrile