N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

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Chemical Name:N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine
CAS No.:1428649-08-4
Molecular Formula:C₂₃H₂₅BrN₄OS
Molecular Weight:485.448
Hs Code.:

Synonyms:N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

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Chemical Property of N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

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Technology Process of N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

There total 3 articles about N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428649-07-3
N-[9-bromo-1'-(4-methoxybenzyl)-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

: 1428649-08-4
N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

Guidance literature:: N-[9-bromo-1'-(4-methoxybenzyl)-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine; With carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With methanol; for 0.166667h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.01.016

Reference yield:

: 1403578-92-6
9-bromo-1'-(4-methoxybenzyl)-2H-spiro[benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin]-6(4H)-imine

: 1428649-08-4
N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: carbonochloridic acid 1-chloro-ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere; Reflux

With carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.016

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 1428649-08-4
N-[9-bromo-2H-spiro(benzo[e]pyrimido[1,2-c][1,3]thiazine-3,4'-piperidin)-6(4H)-ylidene]-1-(4-methoxyphenyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: carbonochloridic acid 1-chloro-ethyl ester; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.17 h / Inert atmosphere; Reflux

With carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.016