5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

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Chemical Name:5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione
CAS No.:808758-86-3
Molecular Formula:C₃₃H₂₇I₂N₃O₂S₂
Molecular Weight:815.537
Hs Code.:

Synonyms:5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

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Chemical Property of 5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

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Technology Process of 5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

There total 4 articles about 5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 808758-88-5
5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

: 5217-47-0
N,N'-diethyl-2-thiobarbituric acid

: 808758-86-3
5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

Guidance literature:: at 20 ℃; for 2h;
DOI:10.1021/ma0491816

Reference yield:

: 808758-81-8
4-[bis-(4-iodophenyl)amino]benzaldehyde

: 808758-86-3
5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / NaOEt / tetrahydrofuran; ethanol / 4 h / Heating

2.1: lithium diisopropylamide / tetrahydrofuran / -78 - 0 °C

2.2: tetrahydrofuran / -40 - 20 °C

2.3: aq. HCl / tetrahydrofuran / 2 h / 20 °C

3.1: 92 percent / 2 h / 20 °C

With sodium ethanolate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; 1.1: Wittig reaction / 3.1: Knoevenagel condensation;
DOI:10.1021/ma0491816

Reference yield:

: 808758-83-0
2-[2-[4-[N,N-di(4-iodophenyl)amino]phenyl]ethenyl]thiophene

: 808758-86-3
5-[5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophen-2-ylmethylene]-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran / -78 - 0 °C

1.2: tetrahydrofuran / -40 - 20 °C

1.3: aq. HCl / tetrahydrofuran / 2 h / 20 °C

2.1: 92 percent / 2 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; 2.1: Knoevenagel condensation;
DOI:10.1021/ma0491816