5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

Base Information

Chemical Name:5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde
CAS No.:808758-88-5
Molecular Formula:C₂₅H₁₇I₂NOS
Molecular Weight:633.291
Hs Code.:

Synonyms:5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

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Chemical Property of 5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

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Technology Process of 5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

There total 3 articles about 5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 808758-83-0
2-[2-[4-[N,N-di(4-iodophenyl)amino]phenyl]ethenyl]thiophene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 5-((Z)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

: 808758-88-5
5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

Guidance literature:: 2-[2-[4-[N,N-di(4-iodophenyl)amino]phenyl]ethenyl]thiophene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -40 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ma0491816

Reference yield:

: 808758-81-8
4-[bis-(4-iodophenyl)amino]benzaldehyde

: 808758-88-5
5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / NaOEt / tetrahydrofuran; ethanol / 4 h / Heating

2.1: lithium diisopropylamide / tetrahydrofuran / -78 - 0 °C

2.2: tetrahydrofuran / -40 - 20 °C

2.3: aq. HCl / tetrahydrofuran / 2 h / 20 °C

With sodium ethanolate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; 1.1: Wittig reaction;
DOI:10.1021/ma0491816

Reference yield:

: 4181-05-9
4-(diphenylamino)benzaldehyde

: 808758-88-5
5-((E)-2-{4-[Bis-(4-iodo-phenyl)-amino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 73 percent / KI; KIO₃; acetic acid / 3 h / 70 °C

2.1: 86 percent / NaOEt / tetrahydrofuran; ethanol / 4 h / Heating

3.1: lithium diisopropylamide / tetrahydrofuran / -78 - 0 °C

3.2: tetrahydrofuran / -40 - 20 °C

3.3: aq. HCl / tetrahydrofuran / 2 h / 20 °C

With potassium iodate; sodium ethanolate; acetic acid; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; 2.1: Wittig reaction;
DOI:10.1021/ma0491816