1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

Base Information

Chemical Name:1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one
CAS No.:186970-53-6
Molecular Formula:C₃₅H₃₇NO₅
Molecular Weight:551.682
Hs Code.:

Synonyms:1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

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Chemical Property of 1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

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Technology Process of 1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

There total 8 articles about 1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-89-4
picoline

: 186970-53-6
1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide, 3.) aq. HCl / 1) THF, hexane, -78 deg C --> rt, 1 h; 2) THF, hexane, rt, 12 h; 3) 10 min

2: 94 percent / Jones reagent / acetone / 0.25 h / -15 °C

3: 1.) NaH / 1) DMF, rt, 4 h; 2) DMF, rt, 48 h

With hydrogenchloride; jones reagent; sodium hydride; lithium diisopropyl amide; In acetone;
DOI:10.1021/jo9618029

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 186970-53-6
1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1) DMF, rt, 4 h; 2) DMF, rt, 48 h

With pyridinium p-toluenesulfonate; sodium hydride; In dichloromethane;
DOI:10.1021/jo9618029

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 186970-53-6
1-[4-(2-Benzyloxy-ethoxy)-phenyl]-2-pyridin-4-yl-4-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N / tetrahydrofuran / 0.5 h / Ambient temperature

2: 85 percent / K₂CO₃ / butan-2-one / 72 h / 80 °C

3: 1.) lithium diisopropylamide, 3.) aq. HCl / 1) THF, hexane, -78 deg C --> rt, 1 h; 2) THF, hexane, rt, 12 h; 3) 10 min

4: 94 percent / Jones reagent / acetone / 0.25 h / -15 °C

5: 1.) NaH / 1) DMF, rt, 4 h; 2) DMF, rt, 48 h

With hydrogenchloride; jones reagent; sodium hydride; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; acetone; butanone;
DOI:10.1021/jo9618029