(R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one

Base Information

• Chemical Name: (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one
• CAS No.: 208338-08-3
• Molecular Formula: C₂₃H₂₁NO₅
• Molecular Weight: 391.423
• Mol file: 208338-08-3.mol

Synonyms:(R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one

Chemical Property of (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one

There total 3 articles about (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester (127536-35-0) → (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one (208338-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / 1M aq. NaOH / acetonitrile / 1 h / Heating

2: 100 percent / thionyl chloride / 15 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 15 min, b) RT, 20 min

With sodium hydroxide; n-butyllithium; thionyl chloride; In acetonitrile;

DOI:10.1016/S0957-4166(98)00087-1

Reference yield:

1,4-dimethoxynaphthalene-2-carboxylic acid (78265-13-1) → (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one (208338-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / thionyl chloride / 15 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 15 min, b) RT, 20 min

With n-butyllithium; thionyl chloride;

DOI:10.1016/S0957-4166(98)00087-1

Reference yield:

(R)-4-(phenylmethyl)-2-oxazolidinone (40217-17-2,90719-32-7,120574-96-1,102029-44-7) + 1,4-dimethoxy-2-naphthoyl chloride (78265-14-2) → (R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one (208338-08-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 15 min, b) RT, 20 min;

DOI:10.1016/S0957-4166(98)00087-1

upstream raw materials:

(R)-4-(phenylmethyl)-2-oxazolidinone

1,4-dimethoxy-2-naphthoyl chloride

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester

1,4-dimethoxynaphthalene-2-carboxylic acid

Downstream raw materials:

2-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-[1,4]naphthoquinone