1,4-Dimethoxy-2-naphthoic acid

Base Information

• Chemical Name: 1,4-Dimethoxy-2-naphthoic acid
• CAS No.: 78265-13-1
• Molecular Formula: C13H12 O4
• Molecular Weight: 232.236
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID60457637
• Nikkaji Number: J899.567B
• Wikidata: Q82280552
• Mol file: 78265-13-1.mol

Synonyms:1,4-dimethoxy-2-naphthoic acid;2MeO-C10COOH

Chemical Property of 1,4-Dimethoxy-2-naphthoic acid

Chemical Property:

• Vapor Pressure: 3.45E-07mmHg at 25°C
• Melting Point: 170-174 °C(lit.)
• Refractive Index: 1.616
• Boiling Point: 402.1°C at 760 mmHg
• Flash Point: 156°C
• PSA: 55.76000
• Density: 1.261g/cm³
• LogP: 2.55520
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 232.07355886
• Heavy Atom Count: 17
• Complexity: 279

Purity/Quality:

98% ^*data from raw suppliers

1,4-Dimethoxy-2-naphthoic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C2=CC=CC=C21)OC)C(=O)O

Technology Process of 1,4-Dimethoxy-2-naphthoic acid

There total 10 articles about 1,4-Dimethoxy-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester (127536-35-0) → 1,4-dimethoxynaphthalene-2-carboxylic acid (78265-13-1)

Guidance literature:

With sodium hydroxide; In acetonitrile; for 1h; Heating;

DOI:10.1016/S0957-4166(98)00087-1

Reference yield: 77.0%

carbon dioxide (124-38-9,18923-20-1) + 2-bromo-1,4-dimethoxynaphthalene (64648-81-3) → 1,4-dimethoxynaphthalene-2-carboxylic acid (78265-13-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - -20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.084

Reference yield: 56.0%

carbon dioxide (124-38-9,18923-20-1) + 1,4-dimethoxynaphthalene (10075-62-4) → 1,4-dimethoxynaphthalene-2-carboxylic acid (78265-13-1)

Guidance literature:

1,4-dimethoxynaphthalene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In hexane; cyclohexane; at 20 ℃; for 2h;

carbon dioxide; In hexane; cyclohexane;

DOI:10.1016/S0040-4020(98)00211-7

upstream raw materials:

1,4-dimethoxynaphthalene-2-carboxylic acid methyl ester

carbon dioxide

1,4-dimethoxynaphthalene

1,4-dimethoxynaphthalene-2-carbaldehyde

Downstream raw materials:

1,4-Dimethoxy-naphthalene-2-carboxylic acid (1R,2S)-2-phenyl-cyclohexyl ester

2-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-[1,4]naphthoquinone

(R)-4-Benzyl-3-(1,4-dimethoxy-naphthalene-2-carbonyl)-oxazolidin-2-one

1,4-Dioxo-1,4-dihydro-naphthalene-2-carboxylic acid (1R,2S)-2-phenyl-cyclohexyl ester

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