4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

Base Information

Chemical Name:4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester
CAS No.:77270-63-4
Molecular Formula:C₂₂H₂₇NO₆
Molecular Weight:401.459
Hs Code.:

Synonyms:4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

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Chemical Property of 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

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Technology Process of 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

There total 6 articles about 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77270-58-7
3-(2-Methoxy-ethoxymethoxy)-2-nitro-phenol

: 77270-63-4
4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂, NaBH₄, 2 N NaOH / 10percent Pd/C / 0.5 h / Ambient temperature

2: 98 percent / K₂CO₃ / acetone / 12 h / Heating

3: 96 percent / NaI, K₂CO₃ / acetone / 15 h / 90 °C

4: 100 percent / 5percent KOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

5: 1.) (i-Pr)2NLi / 1.) THF, -50 deg C, 2 h, 2.) from -50 deg C to room temp.

6: methanol

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; hydrogen; potassium carbonate; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1021/jo00324a054

Reference yield:

: 77270-59-8
2-Amino-3-(2-methoxy-ethoxymethoxy)-phenol

: 77270-63-4
4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / K₂CO₃ / acetone / 12 h / Heating

2: 96 percent / NaI, K₂CO₃ / acetone / 15 h / 90 °C

3: 100 percent / 5percent KOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

4: 1.) (i-Pr)2NLi / 1.) THF, -50 deg C, 2 h, 2.) from -50 deg C to room temp.

5: methanol

With potassium hydroxide; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1021/jo00324a054

Reference yield:

: 77270-60-1
5-(2-Methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

: 77270-63-4
4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaI, K₂CO₃ / acetone / 15 h / 90 °C

2: 100 percent / 5percent KOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

3: 1.) (i-Pr)2NLi / 1.) THF, -50 deg C, 2 h, 2.) from -50 deg C to room temp.

4: methanol

With potassium hydroxide; potassium carbonate; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1021/jo00324a054