N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

Base Information

Chemical Name:N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide
CAS No.:724733-74-8
Molecular Formula:C₂₅H₂₈BrF₃N₂O₄
Molecular Weight:557.408
Hs Code.:

Synonyms:N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

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Chemical Property of N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

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Technology Process of N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

There total 7 articles about N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 28314-80-9
2,4,6-trifluorobenzoic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 724733-51-1
(3S,4S)-4-azido-5-(4-bromobenzyloxy)-3-hydroxypentanoic acid methyl ester

: 724733-74-8
N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

Guidance literature:: Multistep reaction;
DOI:10.1021/jm031106i

Reference yield:

: 4005-46-3,4494-96-6,22248-87-9,142941-40-0
3-deoxy-1,2-O-isopropylidene-D-glucose

: 724733-74-8
N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dibutyl tin oxide / toluene / 5 h / Heating

1.2: 100 percent / tetrabutylammonium bromide / toluene / 90 °C

2.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -15 °C

2.2: diphenylphosphoryl azide / tetrahydrofuran / 0 - 20 °C

3.1: aq. acetic acid / 1 h / Heating

4.1: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C

4.2: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C

4.3: aq. sodium hydroxide / dioxane / 1 h / 20 °C

5.1: acetyl chloride / 48 h / 20 °C

With sodium periodate; di-isopropyl azodicarboxylate; di(n-butyl)tin oxide; acetic acid; acetyl chloride; triphenylphosphine; In tetrahydrofuran; toluene; tert-butyl alcohol;
DOI:10.1021/jm031106i

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 724733-74-8
N-[(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-cyclohexylcarbamoyl-2-hydroxy-propyl]-2,4,6-trifluoro-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dibutyl tin oxide / toluene / 5 h / Heating

1.2: 100 percent / tetrabutylammonium bromide / toluene / 90 °C

2.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / -15 °C

2.2: diphenylphosphoryl azide / tetrahydrofuran / 0 - 20 °C

3.1: aq. acetic acid / 1 h / Heating

4.1: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C

4.2: aq. sodium periodate / 2-methyl-propan-2-ol / 0.25 h / 20 °C

4.3: aq. sodium hydroxide / dioxane / 1 h / 20 °C

5.1: acetyl chloride / 48 h / 20 °C

With sodium periodate; di-isopropyl azodicarboxylate; di(n-butyl)tin oxide; acetic acid; acetyl chloride; triphenylphosphine; In tetrahydrofuran; toluene; tert-butyl alcohol;
DOI:10.1021/jm031106i