3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester
CAS No.:850254-52-3
Molecular Formula:C₂₆H₃₆O₈
Molecular Weight:476.567
Hs Code.:

Synonyms:3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of 3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

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Technology Process of 3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

There total 16 articles about 3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-2-phenylselanyl-cyclohexanecarboxylic acid methyl ester

: 850254-52-3
3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With dihydrogen peroxide; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1055/s-2004-837222

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 850254-52-3
3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 98 percent / tetrahydrofuran / 15 h / 20 °C

2.1: 95 percent / tetrahydrofuran / 18 h / 60 °C

3.1: 95 percent / Br₂; NaOAc; AcOH / 18 h / 20 °C

4.1: 92 percent / p-TsOH / benzene / 14 h / Heating

5.1: 90 percent / H₂ / Wilkinson's catalyst / methanol / 8 h / 20 °C

6.1: Mg / tetrahydrofuran / 2 h / 65 °C

6.2: 50 percent / tetrahydrofuran / 4 h / 0 °C

7.1: 81 percent / NaH / 3 h / Heating

8.1: pyridine / CH₂Cl₂ / 1 h / 0 °C

9.1: H₂O₂ / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; n-butyllithium; hydrogen; dihydrogen peroxide; bromine; sodium acetate; sodium hydride; toluene-4-sulfonic acid; magnesium; acetic acid; Wilkinson's catalyst; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1055/s-2004-837222

Reference yield:

: 6267-39-6
3-ethoxy-5,5-dimethyl-2-cyclohexen-1-one

: 850254-52-3
3-[2-(3-isopropyl-4,5-dimethoxy-phenyl)-2-methoxycarbonyloxy-ethyl]-3,4,4-trimethyl-6-oxo-cyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 97 percent / tetrahydrofuran / 15 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 86 percent / tetrahydrofuran / 15 h / 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 15 h / 20 °C

4.1: aq. HCl / tetrahydrofuran / 10 h / 20 °C

5.1: 74 percent / NaOMe; H₂ / Pd/C / methanol / 6 h / 20 °C

6.1: 95 percent / PDC / CH₂Cl₂ / 4 h / 20 °C

7.1: Mg / tetrahydrofuran / 2 h / 65 °C

7.2: 50 percent / tetrahydrofuran / 4 h / 0 °C

8.1: 81 percent / NaH / 3 h / Heating

9.1: pyridine / CH₂Cl₂ / 1 h / 0 °C

10.1: H₂O₂ / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; hydrogen; dihydrogen peroxide; sodium methylate; sodium hydride; magnesium; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2004-837222