(17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester

Base Information

• Chemical Name: (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester
• CAS No.: 80904-52-5
• Molecular Formula: C₂₈H₃₆O₆S
• Molecular Weight: 500.656
• Mol file: 80904-52-5.mol

Synonyms:(17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester

Chemical Property of (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester

There total 4 articles about (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

testosterone (58-22-0) + methyl benzenesulfonylacetate (34097-60-4) → (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester (80904-52-5,123857-87-4)

Guidance literature:

With sodium hydride; sodium chloride; palladium dichloride; Yield given. Multistep reaction; 1.) THF, 2d, reflux; 2.) DMSO, 2d, room temp.;

DOI:10.1002/jlac.198119811112

Reference yield:

testosterone (58-22-0) + methyl benzenesulfonylacetate (34097-60-4) → (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester (123857-87-4) + (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester (80904-52-5)

Guidance literature:

With sodium hydride; sodium chloride; palladium dichloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) 2 d, heating, THF, 2.) 2 d, RT, DMSO, pentane;

Reference yield:

benzenesulfonylacetic acid (3959-23-7) → (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(phenylsulfonyl)essigsaeure-methylester (80904-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / p-MeC₆H₄SO₃H*H₂O / CCl₄ / 48 h / Heating

2: 1.) PdCl₂, NaCl, 2.) NaH / in paraffine oil / 1.) 2 d, heating, THF, 2.) 2 d, RT, DMSO, pentane

With sodium hydride; toluene-4-sulfonic acid; sodium chloride; palladium dichloride; In tetrachloromethane;

upstream raw materials:

testosterone

methyl benzenesulfonylacetate

benzenesulfonylacetic acid

2-(phenylsulfonyl)acetonitrile