Technology Process of N-[4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenyl]-2-morpholinoacetamide
There total 6 articles about N-[4-(3,5-dicyclopropyl-1H-pyrazol-1-yl)phenyl]-2-morpholinoacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 28 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium ethanolate / dimethyl sulfoxide / 60 °C
2.1: hydrazine hydrate / ethanol / Reflux
3.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 160 °C / Inert atmosphere
3.2: 4 h / 160 °C
4.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux
5.1: dichloromethane / 0.25 h / 0 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0 - 28 °C
With
sodium ethanolate; iron; sodium hydride; ammonium chloride; caesium carbonate; hydrazine hydrate;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrazine hydrate / ethanol / Reflux
2.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 160 °C / Inert atmosphere
2.2: 4 h / 160 °C
3.1: ammonium chloride; iron / ethanol; water / 0.5 h / Reflux
4.1: dichloromethane / 0.25 h / 0 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0 - 28 °C
With
iron; sodium hydride; ammonium chloride; caesium carbonate; hydrazine hydrate;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
