benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

Base Information

Chemical Name:benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate
CAS No.:1190391-55-9
Molecular Formula:C₄₀H₄₅ClN₂O₆Si
Molecular Weight:713.346
Hs Code.:

Synonyms:benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

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Chemical Property of benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

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Technology Process of benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

There total 13 articles about benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1190391-38-8
benzyl [3-(2-oxobut-3-en-1-yl)phenyl]carbamate

: 1190391-41-3
benzyl {(1R)-1-[(R)-{[tert-butyl(dimethyl)silyl]oxy}(3-chlorophenyl)methyl]prop-2-en-1-yl}carbamate

: 1190391-55-9
benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

Guidance literature:: Zhan I catalyst; In dichloromethane; at 40 ℃; Inert atmosphere;

Reference yield:

: 441285-17-2
(3-{[(benzyloxy)carbonyl]amino}phenyl)acetic acid

: 1190391-55-9
benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h

1.2: 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 5 °C

3.1: Zhan I catalyst / dichloromethane / 40 °C / Inert atmosphere

With triethylamine; Zhan I catalyst; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1190391-39-9
ethyl (3-{[(benzyloxy)carbonyl]amino}phenyl)acetate

: 1190391-55-9
benzyl {4-[(3E,5R,6R)-5-{[(benzyloxy)carbonyl]amino}-6-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-chlorophenyl)-2-oxohex-3-en-1-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 20 - 60 °C

1.2: 25 °C / pH 2 - 3

2.1: triethylamine / dichloromethane / 0.17 h

2.2: 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 5 °C

4.1: Zhan I catalyst / dichloromethane / 40 °C / Inert atmosphere

With water; triethylamine; lithium hydroxide; Zhan I catalyst; In tetrahydrofuran; ethanol; dichloromethane;