N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

Base Information

Chemical Name:N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide
CAS No.:847417-33-8
Molecular Formula:C₁₄H₁₈F₂N₂O
Molecular Weight:268.307
Hs Code.:

Synonyms:N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

Chemical Property:

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Technology Process of N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

There total 6 articles about N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 847417-32-7
tert-butyl (1S,3S)-3-{[difluoro(4-methylphenyl)acetyl]amino}cyclopentylcarbamate

: 847417-33-8
N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

Guidance literature:: tert-butyl (1S,3S)-3-{[difluoro(4-methylphenyl)acetyl]amino}cyclopentylcarbamate; With hydrogenchloride; In ethyl acetate; for 1h;

In water; acetonitrile;

Reference yield:

: (1S,3S)-3-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid

: 847417-33-8
N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

1.2: 16 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 1861.78 Torr

3.1: ethanol / 16 h / Heating / reflux

4.1: hydrogenchloride / ethyl acetate / 1 h

4.2: SCX ion exchange resin

With hydrogenchloride; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; ethyl acetate; toluene;

Reference yield:

: 847417-31-6,1315495-87-4,881891-89-0
benzyl tert-butyl (1S,3S)-cyclopentane-1,3-diylbiscarbamate

: 847417-33-8
N-[(1S,3S)-3-aminocyclopentyl]-2,2-difluoro-2-(4-methylphenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 1861.78 Torr

2.1: ethanol / 16 h / Heating / reflux

3.1: hydrogenchloride / ethyl acetate / 1 h

3.2: SCX ion exchange resin

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate;