N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

Base Information

• Chemical Name: N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide
• CAS No.: 1429200-01-0
• Molecular Formula: C₁₈H₂₃BrN₄O₃
• Molecular Weight: 423.31
• Mol file: 1429200-01-0.mol

Synonyms:N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

Chemical Property of N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide

There total 5 articles about N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine (474329-58-3) + 1-cyanoacetyl-3,5-dimethylpyrazole (36140-83-7) → N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide (1429200-01-0)

Guidance literature:

In toluene; at 20 ℃; Reflux;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide (1429200-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 20 h / 70 °C

2: sodium carbonate; sodium dithionate / methanol; water / 70 °C

3: toluene / 20 °C / Reflux

With sodium dithionate; sodium carbonate; triethylamine; In methanol; water; isopropyl alcohol; toluene;

DOI:10.1016/j.bmc.2013.01.064

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-cyanoacetamide (1429200-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 20 h / 70 °C

2: sodium carbonate; sodium dithionate / methanol; water / 70 °C

3: toluene / 20 °C / Reflux

With sodium dithionate; sodium carbonate; triethylamine; In methanol; water; isopropyl alcohol; toluene;

DOI:10.1016/j.bmc.2013.01.064

upstream raw materials:

4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine

1-cyanoacetyl-3,5-dimethylpyrazole

1,4-dibromo-2-nitrobenzene

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

N-(2-(4-benzylpiperazin-1-yl)-5-bromophenyl)-8-methoxy-2-(phenylimino)-2H-chromene-3-carboxamide

N-(2-(4-tert-butoxycarbonylpiperazin-1-yl)-5-bromophenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

N-(5-bromo-2-(piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide

N-(5-bromo-2-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)-2-(phenylimino)-2H-chromene-3-carboxamide