(2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

Base Information

• Chemical Name: (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal
• CAS No.: 1033090-62-8
• Molecular Formula: C₃₂H₅₅N₄O₈PS₂
• Molecular Weight: 718.916

Synonyms:(2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

Chemical Property of (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

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Technology Process of (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

There total 1 articles about (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2S)-N-{4-[4-piperazin-1-ylbutoxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal (956702-30-0) + diethyl 3-(bromopropyl)phosphonic acid (1186-10-3) → (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal (1033090-62-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2008.01.040

Reference yield: 75.0%

(2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal (1033090-62-8) → (2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal (1033090-67-3)

Guidance literature:

With tin(ll) chloride; In methanol; for 4h; Heating;

DOI:10.1016/j.bmc.2008.01.040

upstream raw materials:

(2S)-N-{4-[4-piperazin-1-ylbutoxy]-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

diethyl 3-(bromopropyl)phosphonic acid

Downstream raw materials:

(2S)-N-{4-[4-(4-(3-(diethoxyphosphoryl)propyl)piperazin-1-yl)butyloxy]-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

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