1186-10-3

Usage

Uses

Used in the Chemical Synthesis Industry:
DIETHYL(3-BROMOPROPYL)PHOSPHONATE is used as a reactant for the synthesis of hybrid assemblies composed of titanium dioxide nanoparticles and thin multi-walled carbon nanotubes. This application takes advantage of its reactivity to create innovative materials with unique properties.
Used in the Production of Organosoluble Zirconium Phosphonate Nanocomposites:
In the field of asymmetric hydrogenation, DIETHYL(3-BROMOPROPYL)PHOSPHONATE is utilized as a reactant for the development of organosoluble zirconium phosphonate nanocomposites. These nanocomposites are essential for enhancing the efficiency and selectivity of hydrogenation reactions.
Used in the Synthesis of Cyclic Hydroxamic Acids:
DIETHYL(3-BROMOPROPYL)PHOSPHONATE is employed as a reactant in the synthesis of cyclic hydroxamic acids through alkylation followed by intramolecular cyclization. This process allows for the creation of complex molecules with potential applications in various industries.
Used in the Creation of pH-Responsive Cyclopolymers:
This versatile reactant is also used in the formation of pH-responsive cyclopolymers, which are polymers that can change their properties in response to changes in pH levels. This makes them useful in a variety of applications, such as drug delivery systems and environmental sensors.
Used in the Homogenization of Zirconium Hydroxide Phosphonate Supported Ruthenium Catalyst:
DIETHYL(3-BROMOPROPYL)PHOSPHONATE plays a crucial role in the homogenization process of zirconium hydroxide phosphonate supported ruthenium catalysts. This ensures the even distribution of the catalyst, which is vital for efficient catalytic reactions.
Used in Reactions with Sodium Imidazolide:
In the synthesis of various organic compounds, DIETHYL(3-BROMOPROPYL)PHOSPHONATE is used in reactions with sodium imidazolide. This allows for the formation of new chemical entities with potential applications in pharmaceuticals, materials science, and other fields.

InChI:InChI=1/C7H16BrO3P/c1-3-10-12(9,11-4-2)7-5-6-8/h3-7H2,1-2H3

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 122-52-1 triethyl phosphite 
• 64-17-5 ethanol 
• 106-94-5 propyl bromide 
• 86483-94-5 (3-bromopropyl)phosphonic dichloride 
• 74-96-4 ethyl bromide 
• 78-40-0 triethyl phosphate 
• 762-04-9 phosphonic acid diethyl ester 
• 2303-76-6 sodium diethyl phosphite 

Downstream Products

• 66498-74-6 {3-[(4-Methoxy-benzyloxy)-(toluene-4-sulfonyl)-amino]-propyl}-phosphonic acid diethyl ester 
• 1190-09-6 3-bromopropane-1-phosphonic acid 
• 66508-19-8 3-(N-hydroxyamino)-propylphosphonic acid diethylester 
• 151331-90-7 2-<3-(diethylphosphono)propoxy>benzyl alcohol 
• 126937-45-9 2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate 
• 84390-44-3 (3-{4,6-Bis-(3,5-di-tert-butyl-4-methoxy-phenyl)-7-[3-(ethoxy-hydroxy-phosphoryl)-propoxy]-5-hydroxy-5-oxo-5H-5λ⁵-dibenzophosphol-3-yloxy}-propyl)-phosphonic acid monoethyl ester 
• 18812-51-6 diethyl propylphosphonate 
• 1068-06-0 diethyl 6-oxo-n-heptylphosphonate 
• 1027541-40-7 [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-phosphonic acid diethyl ester 
• 202828-72-6 Diethyl 3-amino>propyl-1-phosphonate 
• 87213-51-2 1-diethylphosphonato-3-(diphenylphosphino)propane 
• 1244590-97-3 BrH*C₁₈H₂₆N₃O₄P 
• 1401988-87-1 tert-butyl benzyloxy(3-(diethoxyphosphoryl)propyl)carbamate 
• 1422188-76-8 C₄₁H₇₂N₅O₁₁P 

Relevant academic research and scientific papers

Tetra-Substituted p-Tert-Butylcalix[4]Arene with Phosphoryl and Salicylamide Functional Groups: Synthesis, Complexation and Selective Extraction of f-Element Cations

A new series of lanthanide (1–5) and uranyl (6) complexes with a tetra-substituted bifunctional calixarene ligand H2L is described. The coordination environment for the Ln3+ and UO22+ ions is provided by phosphoryl and salicylamide functional groups appended to the lower rim of the p-tert-butylcalix[4]arene scaffold. Ligand interactions with lanthanide cations (light: La3+, Pr3+; intermediate: Eu3+ and Gd3+; and heavy: Yb3+), as well as the uranyl cation (UO22+) is examined in the solution and solid state, respectively with spectrophotometric titration and single crystal X-ray diffractometry. The ligand is fully deprotonated in the complexation of trivalent lanthanide ions forming di-cationic complexes 2 : 2 M : L, [Ln2(L)2(H2O)]2+ (1–5), in solution, whereas uranyl formed a 1 : 1 M : L complex [UO2(L)(MeOH)]∞ (6) that demonstrated very limited solubility in 12 organic solvents. Solvent extraction behaviour is examined for cation selectivity and extraction efficiency. H2L was found to be an effective extracting agent for UO22+ over La3+ and Yb3+ cations. The separation factors at pH 6.0 are: βUO (Formula presented.) /La (Formula presented.) =121.0 and βUO (Formula presented.) /Yb (Formula presented.) =70.0.

The hydrophilizing agent for producing a self-emulsifiable polyisocyanate composition, a self-emulsifiable polyisocyanate compositions and coating composition (by machine translation)

[A] a self-emulsifiable polyisocyanate composition has excellent adhesion to the substrate of a metal such as aluminum. (A) a compound represented by the formula [a] 1 anionic and, (b) organic polyisocyanate, and (c) a self-emulsifiable polyisocyanate com

IONIC LIQUID

Ionic liquids are described which have a very broad electrochemical stability window and which are therefore of high utility for a wide range of electrochemical energy storage device applications.

Synthesis and biological activity investigation of azole and quinone hybridized phosphonates

Phosphonates, azoles and quinones are pharmacophores found in bioactive compounds. A series of phosphonates conjugated to azoles and quinones with variable carbon chain lengths were synthesized in 3–4 steps with good yield. Antifungal assay of these compounds showed that ethyl protected phosphates have excellent inhibitory activity against phytopathogenic fungus Fusarium graminearum, and the free-base phosphates have good activity against human pathogenic fungi Aspergillus flavus and Candida albicans. Structure- activity relationship (SAR) studies showed activity increases with longer carbon chain length between phosphonate and anthraquinone analogs consisting of azole and quinone moieties. These newly synthesized compounds also have mild antibacterial activities to Gram positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Cytotoxicity analysis of these compounds against HeLa cells reveals that the phosphoric acid analogs are less toxic compared to ethyl protected phosphonates. Three leads compounds have been identified with prominent antifungal activity and low cytotoxicity.

Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds

Phosphonates have garnered considerable attention for years owing to both their singular biological properties and their synthetic potential. State-of-the-art methods for the preparation of mixed phosphonates, phosphonamidates, phosphonothioates, and phos

Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).

COMPOUND, SURFACE TREATMENT AGENT, AND SURFACE TREATMENT METHOD

PROBLEM TO BE SOLVED: To provide a novel compound which is suitable for use as a surface treatment agent and has high stability, a surface treatment agent containing the compound, and a surface treatment method. SOLUTION: The compound is represented by formula (I) (R1 to R4 are each independently H, an alkyl group, or an alkoxy group which may have a perfluoroalkyl group as a substituent; R5 is H or a C1-6 alkyl group which may have a halogen atom as a substituent; X is a group represented by -OCONH-, -OCOS-, -OCOO-, -NH-, -S-, -O-, or -OCO-; when X is other than -OCO-, R6 is an alkylene group; and when X is -OCO-, R6 is a single bond or an alkylene group). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT

Co(II)4Gd(III)6 phosphonate grid and cage as molecular refrigerants

The study on structure-property relationships of polynuclear 3d-Gd clusters are very essential in the fields of magnetic refrigerants. We designed two new bulky phosphonic acids: (3-(9H-carbazol-9-yl)propyl)phosphonic acid (CarbpPO3H2) and (2-(9-methyl-9H-fluoren-9-yl)ethyl)phosphonic acid (FlumePO3H2). Based on these ligands, two clusters [Co(II)4Gd(III)6(CarbpPO3)6(tBuCO2)14(tBuCO2H)(H2O)3].9CH3CN.CH2Cl2 (1) and [Co(II)4Gd(III)6(FlumePO3)3(tBuCO2)14(μ3-OH)6(H2O)2(CH3CN)].6CH3CN (2) were synthesized under ambient condition. Compound 1 has a [3 × 3] grid-like structure, while compound 2 has a rare helmet-like cage structure. The magnetocaloric effect (MCE) have been tuned from 22.83 to 29.06 J kg-1 K-1 as the molecular structure changes from grid to cage.

An efficient nonconventional glycerol-based solid acid catalyzed synthesis and biological evaluation of phosphonate conjugates of 1,2,4-triazole thiones

A series of diethyl (3-((5-aryl-1H-1,2,4-triazol-3-yl)thio)propyl)phos-phonates (7a-t) has been synthesized in excellent yields by coupling diethyl (3-bromopropyl)phosphonate and 5-aryl-1H- 1,2,4-triazol-3-thiones employing an efficient, green and nonconventional heterogeneous SO3Hcarbon catalyst derived from glycerol. In addition, a facile and green approach for the esterification of carboxylic acids by utilizing glycerol-based solid acid catalyst has been reported. Structures of the synthesized compounds were characterized by IR, NMR and HRMS studies. These triazole derivatives were screened for their in vitro cytotoxicity using the standard MTT (3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetra-zolium bromide) assay against a panel of five different human cancer cell lines (HeLa: Cervix, A549: Lung, A375: Skin, MDA-MB-231: Breast and T98G: Brain). The antimicrobial activities of the synthesized compounds were investigated against four bacterial strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and three fungal strains: Aspergillus Niger, Aspergillus terreus, Aspergillus fumigatus. Preliminary results indicate that the compound 7f displayed maximum anticancer activity and the compounds 7d, 7e, 7f, 7m and 7q exhibited moderate antibacterial activity. The compounds 7g, 7h, 7o and 7p showed good antifungal activity with high inhibition zone diameter compared to the standard drug.

Synthesis of advanced fluorescent probes — water-soluble symmetrical tricarbocyanines with phosphonate groups

A method for the synthesis of a series of water-soluble heptamethine indocyanine dyes containing a phosphonate group in the substituent bonded to the quaternary nitrogen atom of the indolenine moiety has been developed.