(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

Base Information

Chemical Name:(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea
CAS No.:1323276-24-9
Molecular Formula:C₂₁H₂₅FN₄O₄
Molecular Weight:416.452
Hs Code.:

Synonyms:(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

Suppliers and Price of (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

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Technology Process of (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

There total 6 articles about (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1355672-53-5
C₁₁H₁₆FN₃O₂

: 93744-18-4
(S)-(+)-3-(2-cyanophenoxy)-1,2-epoxypropane

: 1323276-24-9
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

Guidance literature:: With diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In acetonitrile; at 74 - 85 ℃;
DOI:10.1021/ml1002458

Reference yield:

: 367260-94-4
4-nitrophenyl 3-(benzyloxy)phenylcarbamate

: 1323276-24-9
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With hydrogenchloride; palladium on activated charcoal; diethyl methoxy borane; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml1002458

Reference yield:

: 1323276-70-5
tert-butyl 2-(3-(3-(benzyloxy)phenyl)ureido)ethylcarbamate

: 1323276-24-9
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / ethanol / 2585.81 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With hydrogenchloride; palladium on activated charcoal; diethyl methoxy borane; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ml1002458