367260-94-4

Upstream product

• 1484-26-0 3-(benzyloxy)aniline 
• 7693-46-1 4-Nitrophenyl chloroformate 

Downstream Products

• 1323276-24-9 (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-(2-fluoroethoxy)phenyl)urea 
• 1323276-85-2 (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-benzyloxyphenyl) urea 
• 1323276-87-4 (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(3-hydroxyphenyl)urea 
• 1355672-53-5 C₁₁H₁₆FN₃O₂ 
• 1323277-28-6 C₁₆H₁₉N₃O₂ 
• 1323277-71-9 C₂₁H₂₅⁽¹⁸⁾FN₄O₄ 
• 1323276-71-6 tert-butyl 2-(3-(3-hydroxyphenyl)ureido)ethylcarbamate 
• 1323276-74-9 tert-butyl 2-(3-(3-(2-fluoroethoxy)phenyl)ureido)ethylcarbamate 
• 1323276-70-5 tert-butyl 2-(3-(3-(benzyloxy)phenyl)ureido)ethylcarbamate 
• 367258-95-5 (5S,8S,10R)-5-Cyclohexyl-3,6-dioxo-11,15-dioxa-2,4,7-triaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-8-carboxylic acid 
• 367260-96-6 (5S,8S,10R)-5-Cyclohexyl-3,6-dioxo-11,15-dioxa-2,4,7-triaza-tricyclo[14.3.1.1^7,10]henicosa-1⁽¹⁹⁾,16⁽²⁰⁾,17-triene-8-carboxylic acid methyl ester 
• 367258-92-2 (2S,4R)-1-{(S)-2-[3-(3-Benzyloxy-phenyl)-ureido]-2-cyclohexyl-acetyl}-4-(3-benzyloxy-propoxy)-pyrrolidine-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and cardiac imaging of 18F-ligands selective for β1-adrenoreceptors

A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/ β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribution studies demonstrated uptake of each radiotracers from the blood pool into the myocardium (0.48-0.62% ID/g), lung (0.63-0.97% ID/g), and liver (1.03-1.14% ID/g). Dynamic μPET imaging confirmed the in vivo dissection studies.

P2-P4 Macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.