1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:221012-41-5
Molecular Formula:C₄₀H₃₇N₃O₆S
Molecular Weight:687.816
Hs Code.:

Synonyms:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 1 articles about 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2637-37-8
Quinoline-2-thiol

: 143527-01-9
1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine

: 221012-41-5
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/S0040-4039(98)02694-X

Reference yield:

: 221012-41-5
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: C₃₇H₄₆N₄O₈S₂Si

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / MsOH / methanol; CH₂Cl₂

2: 71 percent / Bz₂O₂

3: 82 percent / NIS

4: 94 percent / DBU / dimethylformamide; formamide

5: 1.) NaBCNH₃, 2.) H₂O / 1.) AcOH, 3 h, 2.) AcOH, 30 min

With N-iodo-succinimide; methanesulfonic acid; water; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; dibenzoyl peroxide; In methanol; dichloromethane; formamide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)02694-X

Reference yield:

: 221012-41-5
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 221012-48-2
C₄₆H₅₁N₅O₈S₂Si

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / MsOH / methanol; CH₂Cl₂

2: 71 percent / Bz₂O₂

3: 82 percent / NIS

4: 94 percent / DBU / dimethylformamide; formamide

With N-iodo-succinimide; methanesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; dibenzoyl peroxide; In methanol; dichloromethane; formamide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)02694-X