221012-48-2

Upstream product

• 221012-47-1 3'-deoxy-3'-thio-5'-O-(tert-butyldimethylsilyl)thymidine 
• 221012-44-8 Diphenyl-phosphinic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-ylmethoxymethyl ester 
• 2637-37-8 Quinoline-2-thiol 
• 143527-01-9 1-(2'-deoxy-3'-O-mesyl-5'-O-4,4'-dimethoxytrityl-β-D-threo-pentofuranosyl)-thymine 
• 221012-41-5 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 221012-46-0 1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 221012-43-7 5-Methyl-1-[(2R,4S,5R)-5-methylsulfanylmethoxymethyl-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 221012-42-6 1-[(2R,4S,5R)-5-Hydroxymethyl-4-(quinolin-2-ylsulfanyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

A novel thiol protecting group: A 2-thioquinoline sulfide as a masked sulfhydryl moiety

2-Thioquinoline sulfide was developed as a masked sulfhydryl entity. It is introduced through facile S(N)2 displacement reactions and is stable to a variety of reaction conditions including acids, bases and nucleophiles. It is readily unmasked using the mild treatment of sodium cyanoborohydride in acetic acid.