3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

Base Information

Chemical Name:3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid
CAS No.:943345-03-7
Molecular Formula:C₂₆H₁₈FN₃O₄
Molecular Weight:455.445
Hs Code.:

Synonyms:3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

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Chemical Property of 3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

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Technology Process of 3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

There total 5 articles about 3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.2%

: 943345-02-6
3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

: 943345-03-7
3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

Guidance literature:: 3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 1h;

With hydrogenchloride; In water; Cooling with ice;

Reference yield:

: 158196-47-5
methyl 2-(3-aminophenoxy)acetate

: 943345-03-7
3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.5 h / 150 °C

2.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate / 20 °C / 2250.23 Torr / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

3.2: Cooling with ice

With water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 554-84-7
meta-nitrophenol

: 943345-03-7
3-{[5-(4-Fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetone / 1 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Inert atmosphere

3.1: 1.5 h / 150 °C

4.1: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate / 20 °C / 2250.23 Torr / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

5.2: Cooling with ice

With water; hydrogen; caesium carbonate; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone;