3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

Base Information

Chemical Name:3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester
CAS No.:943345-02-6
Molecular Formula:C₂₇H₂₀FN₃O₄
Molecular Weight:469.472
Hs Code.:

Synonyms:3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

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Chemical Property of 3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

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Technology Process of 3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

There total 4 articles about 3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.3%

: 943345-01-5
3-{[6-(4-Bromophenyl)-5-(4-fluorophenyl)furo[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

: 943345-02-6
3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; at 20 ℃; under 2250.23 Torr; Inert atmosphere;

Reference yield:

: 554-84-7
meta-nitrophenol

: 943345-02-6
3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetone / 1 h / 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Inert atmosphere

3: 1.5 h / 150 °C

4: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate / 20 °C / 2250.23 Torr / Inert atmosphere

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; acetone;

Reference yield:

: 158196-47-5
methyl 2-(3-aminophenoxy)acetate

: 943345-02-6
3-{[5-(4-fluorophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenoxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate / 20 °C / 2250.23 Torr / Inert atmosphere

With hydrogen; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;