Technology Process of 6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinic acid
There total 4 articles about 6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 6-(2,6-difluoro-4-methylphenyl)-5-fluoropicolinate;
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
With
hydrogenchloride;
In
water;
pH=4;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium permanganate / water / 53 h / 100 °C
2: sulfuric acid / 2 h / 20 °C
3: potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); triisobutylphosphane / tetrahydrofuran; water / 1 h / 80 °C
4: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C
With
potassium fluoride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium(0); triisobutylphosphane; sulfuric acid; water; lithium hydroxide;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / 2 h / 20 °C
2: potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); triisobutylphosphane / tetrahydrofuran; water / 1 h / 80 °C
3: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C
With
potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); triisobutylphosphane; sulfuric acid; water; lithium hydroxide;
In
tetrahydrofuran; water;
