DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

Base Information

Chemical Name:DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester
CAS No.:173282-20-7
Molecular Formula:C₂₁H₃₀F₂N₂O₅
Molecular Weight:428.476
Hs Code.:

Synonyms:DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

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Chemical Property of DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

Chemical Property:

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Technology Process of DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

There total 7 articles about DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 173282-19-4
DL-N-<4-benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

: 173282-20-7
DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; for 8h; under 1551.4 Torr;
DOI:10.1021/jm950514m

Reference yield:

: 173282-21-8
DL-4,4-difluoroglutamic acid

: 173282-20-7
DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / conc. H₂SO₄ / CH₂Cl₂ / 120 h / Ambient temperature

2: 1.) DCC, HOBt / 1.) DMF, RT, 5 min, 2.) DMF, RT, 14 h

3: 69 percent / H₂ / Pd(OH)2/C / ethanol / 8 h / 1551.4 Torr

With sulfuric acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium dihydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm950514m

Reference yield:

: 2-Amino-4-diethylcarbamoyl-4,4-difluoro-butyric acid ethyl ester

: 173282-20-7
DL-N-<4-(methylamino)benzoyl>-4,4-difluoroglutamic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 12 N aq. HCl / 12 h / 100 °C

2: 80 percent / conc. H₂SO₄ / CH₂Cl₂ / 120 h / Ambient temperature

3: 1.) DCC, HOBt / 1.) DMF, RT, 5 min, 2.) DMF, RT, 14 h

4: 69 percent / H₂ / Pd(OH)2/C / ethanol / 8 h / 1551.4 Torr

With hydrogenchloride; sulfuric acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium dihydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm950514m