173282-19-4Relevant academic research and scientific papers
Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-γ,γ-difluoromethotrexate
Tsukamoto, Takashi,Kitazume, Tomoya,McGuire, John J.,Coward, James K.
, p. 66 - 72 (1996)
DL-4,4-Difluoroglutamic acid (DL-4,4-F2Glu) and its methotrexate analogue, DL-γ,γ-difluoromethotrexate (DL-γ,γ-F2MTX), were synthesized and evaluated as alternate substrates or inhibitors of folate-dependent enzymes. Synthesis of DL-
