ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

Base Information

Chemical Name:ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate
CAS No.:1012052-17-3
Molecular Formula:C₁₇H₂₂ClNO₄
Molecular Weight:339.819
Hs Code.:

Synonyms:ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

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Chemical Property of ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

Chemical Property:

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Technology Process of ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

There total 6 articles about ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: (E)-tert-butyl 4-chlorobenzylidenecarbamate

: ethyl (S)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

: 1012052-17-3
ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

Guidance literature:: ethyl (triphenylphosphoranylidene)acetate; (E)-tert-butyl 4-chlorobenzylidenecarbamate; With 4 A molecular sieve; (R,R)-N,N'-bis(3,5-(CF₃)2C₆H₆NHCSNH)-1,2-cyclohexanediamine; In m-xylene; at -20 ℃; for 60h;

formaldehyd; In tetrahydrofuran; water; at 20 ℃; for 24h; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ja7114844

Reference yield:

: C₂HF₃O₂*C₁₂H₁₄ClNO₂

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 1012052-17-3
ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

Guidance literature:: With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h; pH=13;
DOI:10.1002/ejoc.201101244

Reference yield:

: 1361200-79-4
ethyl 2-[(R)-(4-chlorophenyl){[(S)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

: 1012052-17-3
ethyl (R)-2-{[(tert-butoxycarbonyl)amino](4-chlorophenyl)methyl}acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 8 h / Reflux

2: sodium hydroxide / dichloromethane; water / 2 h / 20 °C / pH 13

With sodium hydroxide; In dichloromethane; water;
DOI:10.1002/ejoc.201101244