N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid

Base Information

• Chemical Name: N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid
• CAS No.: 247132-57-6
• Molecular Formula: C₂₆H₃₂N₂O₇
• Molecular Weight: 484.549
• Mol file: 247132-57-6.mol

Synonyms:N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid

Chemical Property of N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid

There total 3 articles about N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-(N-benzyloxycarbonyl-N-ethoxycarbonyl-methylamino)phenoxy]piperidine-1-carboxylic acid tert-butyl ester (247132-56-5) → N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid (247132-57-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 1h;

DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid (247132-57-6)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol; tetrahydrofuran / 3 h / 20 °C / 2280 Torr

2: aq. NaHCO₃ / tetrahydrofuran / 1 h / 20 °C

3: NaH / dimethylformamide / 2 h / 20 °C

4: NaOH / tetrahydrofuran; ethanol / 1 h / 50 °C

With sodium hydroxide; hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.06.009

Reference yield:

tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate (138227-63-1) → N-[4-(1-tert-butoxycarbonylpiperidin-4-yloxy)phenyl]-N-benzyloxycarbonyl-aminoacetic acid (247132-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaHCO₃ / tetrahydrofuran / 1 h / 20 °C

2: NaH / dimethylformamide / 2 h / 20 °C

3: NaOH / tetrahydrofuran; ethanol / 1 h / 50 °C

With sodium hydroxide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.06.009

upstream raw materials:

4-[4-(N-benzyloxycarbonyl-N-ethoxycarbonyl-methylamino)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

Downstream raw materials:

4-[4-[N-Benzyloxycarbonyl-N-(2-tert-butoxycarbonylmethylamino-5-cyanophenyl)carbamoylmethylamino]phenoxy]piperidine-1-carboxylic Acid tert-Butyl Ester

2-[4-(1-tert-Butoxycarbonylpiperidin-4-yloxy)phenylaminomethyl]-1-(cyclohexylcarbamoylmethyl)-5-cyanobenzimdazole

N-(5-carbamimidoyl-1-cyclohexylcarbamoylmethyl-1H-benzoimidazol-2-ylmethyl)-N-[4-(piperidin-4-yloxy)-phenyl]-terephthalamic acid methyl ester