1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE
• CAS No.: 138227-63-1
• Molecular Formula: C16H24N2O3
• Molecular Weight: 292.378
• Hs Code.: 2921490090
• Mol file: 138227-63-1.mol

Synonyms:1-[(N-tert-Butoxycarbonyl-4-piperidinyl)oxy]-4-aminobenzene;4-(1-tert-Butoxycarbonylpiperidin-4-yloxy)aniline;4-(4-Aminophenoxy)-1-(tert-butoxycarbonyl)piperidine;4-(4-Aminophenoxy)piperidine-1-carboxylic acid tert-butyl ester;4-[(1-tert-Butoxycarbonyl-4-piperidyl)oxy]aniline;

Chemical Property of 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 430.312 °C at 760 mmHg
• Flash Point: 214.045 °C
• PSA: 64.79000
• Density: 1.14 g/cm³
• LogP: 3.56620
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-Aminophenoxy)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE

There total 10 articles about 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate (138227-63-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;

DOI:10.1248/cpb.56.758

Reference yield: 99.0%

ethyl acetate (141-78-6) + tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate (138227-63-1)

Guidance literature:

palladium; In methanol; hexane;

Reference yield: 99.0%

→ tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate (138227-63-1)

Guidance literature:

upstream raw materials:

4-amino-phenol

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

4-Fluoronitrobenzene

Downstream raw materials:

7-({4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-anilino}methyl)naphthalene-2-carbonitrile

N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}methanesulfonamide

3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

4-{4-[(3'-carbamimidoyl-biphenyl-4-ylmethyl)-methanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Nirogi, Ramakrishna,Shinde, Anil,Mohammed, Abdul Rasheed,Badange, Rajesh Kumar,Reballi, Veena,Bandyala, Thrinath Reddy,Saraf, Sangram Keshari,Bojja, Kumar,Manchineella, Sravanthi,Achanta, Pramod Kumar,Kandukuri, Kiran Kumar,Subramanian, Ramkumar,Benade, Vijay,Palacharla, Raghava Choudary,Jayarajan, Pradeep,Pandey, Santoshkumar,Jasti, Venkat. "Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity". . p. 1203 - 1217. Retrieved 2019/02/24.
• 2、 -. "SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS". Page/Page column 51; 52. . Retrieved 2018/09/25.