3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide
CAS No.:1341129-00-7
Molecular Formula:C₁₉H₂₂N₄O₂S
Molecular Weight:370.475
Hs Code.:

Synonyms:3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

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Technology Process of 3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

There total 2 articles about 3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1341129-03-0
1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

: 1341129-00-7
3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: With sodium nitrate; In trifluoroacetic acid; at 0 - 20 ℃;
DOI:10.1021/jm201108k

Reference yield:

: 100957-85-5
1-benzyl-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid

: 1341129-00-7
3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: sodium nitrate / trifluoroacetic acid / 0 - 20 °C

With sodium nitrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; trifluoroacetic acid;
DOI:10.1021/jm201108k