1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: 1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide
• CAS No.: 1341129-03-0
• Molecular Formula: C₁₉H₂₁ClN₄OS
• Molecular Weight: 388.921
• Mol file: 1341129-03-0.mol

Synonyms:1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

Chemical Property of 1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide

There total 1 articles about 1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(chloromethyl)thiazol-2-amine hydrochloride (59608-97-8) + 1-benzyl-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid (100957-85-5) → 1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide (1341129-03-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm201108k

Reference yield: 72.0%

1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide (1341129-03-0) → 3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide (1341129-00-7)

Guidance literature:

With sodium nitrate; In trifluoroacetic acid; at 0 - 20 ℃;

DOI:10.1021/jm201108k

Reference yield: 58.0%

1-benzyl-3-tert-butyl-N-(4-chloromethylthiazol-2-yl)-1H-pyrazole-5-carboxamide (1341129-03-0) + dimethyl amine (124-40-3) → 3-tert-butyl-1-benzyl-N-{4-[(dimethylamino)methyl]thiazol-2-yl}-1H-pyrazole-5-carboxamide (1341128-95-7)

Guidance literature:

In methanol; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm201108k

upstream raw materials:

4-(chloromethyl)thiazol-2-amine hydrochloride

1-benzyl-3-(tert-butyl)-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

3-tert-butyl-1-benzyl-N-{4-[(methanesulfonamido)methyl]thiazol-2-yl}-1H-pyrazole-5-carboxamide

3-tert-butyl-1-benzyl-N-[4-(hydroxymethyl)thiazol-2-yl]-1H-pyrazole-5-carboxamide

3-tert-butyl-N-(4-(aminomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide

3-tert-butyl-N-(4-(acetamidomethyl)thiazol-2-yl)-1-benzyl-1H-pyrazole-5-carboxamide