4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

Base Information

Chemical Name:4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate
CAS No.:1380328-61-9
Molecular Formula:C₃₁H₂₆F₃N₃O₈S
Molecular Weight:657.624
Hs Code.:

Synonyms:4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

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Chemical Property of 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

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Technology Process of 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

There total 8 articles about 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1380328-60-8
4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

: 1380328-61-9
4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.04.012

Reference yield:

: C₁₂H₅Cl₃F₃NO₄

: 1380328-61-9
4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With triethylsilane; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2012.04.012

Reference yield:

: 1380328-56-2
methyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

: 1380328-61-9
4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / methanol; water / 1.5 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 5 h / 20 °C

3: Amberlyst-15 / methanol / 2 h / 20 °C

4: dichloromethane / 2 h / 20 °C / Inert atmosphere

5: triethylsilane; trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With triethylsilane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.04.012