4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

Base Information

• Chemical Name: 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate
• CAS No.: 1380328-60-8
• Molecular Formula: C₅₀H₄₀F₃N₃O₈S
• Molecular Weight: 899.944
• Mol file: 1380328-60-8.mol

Synonyms:4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

Chemical Property of 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

There total 8 articles about 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H5Cl3F3NO4 + 4-(hydroxymethyl)phenyl 2-(2-(2-phenylacetamido)-acetamido)-3-(tritylthio)propanoate (1380328-59-5) → 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate (1380328-60-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.04.012

Reference yield:

methyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate (1380328-56-2) → 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate (1380328-60-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / methanol; water / 1.5 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 5 h / 20 °C

3: Amberlyst-15 / methanol / 2 h / 20 °C

4: dichloromethane / 2 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.04.012

Reference yield:

phenylacetylglycine (500-98-1) → 4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate (1380328-60-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

1.2: 26 h / 20 °C

2.1: sodium hydroxide / methanol; water / 1.5 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 5 h / 20 °C

4.1: Amberlyst-15 / methanol / 2 h / 20 °C

5.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.04.012

upstream raw materials:

phenylacetylglycine

4-(hydroxymethyl)phenyl 2-(2-(2-phenylacetamido)-acetamido)-3-(tritylthio)propanoate

methyl 2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoate

2-(2-(2-phenylacetamido)acetamido)-3-(tritylthio)propanoic acid

Downstream raw materials:

4-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-ylcarbamoyloxy)methyl)phenyl-3-mercapto-2-(2-(2-phenylacetamido)acetamido)propanoate

C₆₁H₇₇F₃N₄O₂₁S₂