4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

Base Information

Chemical Name:4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile
CAS No.:1416242-46-0
Molecular Formula:C₁₅H₁₅N₃
Molecular Weight:237.304
Hs Code.:

Synonyms:4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

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Chemical Property of 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

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Technology Process of 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

There total 3 articles about 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416244-50-2
(+/-)-4-(3,3-Dimethyl-4-oxo-cyclopentyl)benzonitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1416242-46-0
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

Guidance literature:: (+/-)-4-(3,3-Dimethyl-4-oxo-cyclopentyl)benzonitrile; N,N-dimethyl-formamide dimethyl acetal; at 100 ℃; for 16h;

With hydrazine hydrate; acetic acid; In isopropyl alcohol; at 80 ℃; for 12h;

Reference yield:

: 4541-32-6
2,2-dimethylcyclopentanone

: 1416242-46-0
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; allyl diethyl phosphate / palladium diacetate / tert-Amyl alcohol / 12 h / 80 °C

2.1: potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / chloro(1,5-cyclooctadiene)rhodium(I) dimer / tetrahydrofuran / Inert atmosphere

3.1: 16 h / 100 °C

3.2: 12 h / 80 °C

With allyl diethyl phosphate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; palladium diacetate; In tetrahydrofuran; tert-Amyl alcohol;

Reference yield:

5,5-dimethylcyclopent-2-enone: 17197-84-1
5,5-dimethylcyclopent-2-enone

: 1416242-46-0
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / chloro(1,5-cyclooctadiene)rhodium(I) dimer / tetrahydrofuran / Inert atmosphere

2.1: 16 h / 100 °C

2.2: 12 h / 80 °C

With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran;