4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

Base Information

Chemical Name:4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate
CAS No.:1416242-52-8
Molecular Formula:C₁₅H₁₅N₃*H₃O₄P
Molecular Weight:335.299
Hs Code.:

Synonyms:4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

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Chemical Property of 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

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Technology Process of 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

There total 4 articles about 4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1416242-46-0
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile

: 1416242-52-8
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

Guidance literature:: With phosphoric acid; In Isopropyl acetate;

Reference yield:

5,5-dimethylcyclopent-2-enone: 17197-84-1
5,5-dimethylcyclopent-2-enone

: 1416242-52-8
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / chloro(1,5-cyclooctadiene)rhodium(I) dimer / tetrahydrofuran / Inert atmosphere

2.1: 16 h / 100 °C

2.2: 12 h / 80 °C

3.1: phosphoric acid / Isopropyl acetate

With phosphoric acid; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In tetrahydrofuran; Isopropyl acetate;

Reference yield:

: 4541-32-6
2,2-dimethylcyclopentanone

: 1416242-52-8
4-[(4R)-6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl]benzonitrile phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; allyl diethyl phosphate / palladium diacetate / tert-Amyl alcohol / 12 h / 80 °C

2.1: potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / chloro(1,5-cyclooctadiene)rhodium(I) dimer / tetrahydrofuran / Inert atmosphere

3.1: 16 h / 100 °C

3.2: 12 h / 80 °C

4.1: phosphoric acid / Isopropyl acetate

With allyl diethyl phosphate; phosphoric acid; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; chloro(1,5-cyclooctadiene)rhodium(I) dimer; palladium diacetate; In tetrahydrofuran; tert-Amyl alcohol; Isopropyl acetate;