1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol

Base Information

• Chemical Name: 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol
• CAS No.: 354147-36-7
• Molecular Formula: C₂₅H₂₂ClNO
• Molecular Weight: 387.909
• Mol file: 354147-36-7.mol

Synonyms:1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol

Chemical Property of 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol

There total 2 articles about 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 4-chlorobenzaldehyde (104-88-1) + β-naphthol (135-19-3) → 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol (354147-36-7)

Guidance literature:

(R)-1-phenyl-ethyl-amine; 4-chlorobenzaldehyde; With chloro-trimethyl-silane; lithium perchlorate; In diethyl ether; at 20 ℃;

β-naphthol; In diethyl ether; at 20 ℃; for 6h;

DOI:10.1016/S0957-4166(02)00863-7

Reference yield: 72.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 4-chlorobenzaldehyde (104-88-1) + β-naphthol (135-19-3) → 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol (354147-36-7) + 1-[(S)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol

Guidance literature:

at 60 ℃; for 7h;

DOI:10.1021/jo0101205

Reference yield: 99.5%

benzyl chloroformate (501-53-1,94274-21-2) + 1-[(R)-(4-chlorophenyl)[[(1'R)-1'-phenylethyl]amino]methyl]-2-naphthol (354147-36-7) → benzyl [(R)-(4-chlorophenyl)(2-hydroxynaphthalen-1-yl)methyl][(R)-1-phenylethyl]carbamate (1033590-48-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1055/s-2008-1032199

upstream raw materials:

(R)-1-phenyl-ethyl-amine

4-chlorobenzaldehyde

β-naphthol

Downstream raw materials:

benzyl [(R)-(4-chlorophenyl)(2-hydroxynaphthalen-1-yl)methyl][(R)-1-phenylethyl]carbamate