2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid
CAS No.:862854-52-2
Molecular Formula:C₂₀H₂₅N₃O₆
Molecular Weight:403.435
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Synonyms:2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

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Chemical Property of 2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

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Technology Process of 2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

There total 3 articles about 2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186792-13-2
4-bromo-5-methoxy-2-methylpyridazin-3(2H)-one

: 119771-23-2
N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine

: 862854-52-2
2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: 4-bromo-5-methoxy-2-methylpyridazin-3(2H)-one; N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine; With sodium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In water; acetonitrile; for 1h; Heating / reflux;

With sodium hydrogencarbonate; In water;

With hydrogenchloride; In water; at 0 ℃; pH=2; Product distribution / selectivity;

Reference yield:

: (S)-2-Amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid; compound with trifluoro-acetic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 862854-52-2
2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile; at 23 ℃; for 18h;
DOI:10.1021/jm060031q

Reference yield:

: 862854-53-3
C₂₁H₂₇N₃O₆

: 862854-52-2
2-tert-butoxycarbonylamino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid

Guidance literature:: C₂₁H₂₇N₃O₆; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 23 ℃; for 4h;

With hydrogenchloride; water; at 0 ℃; pH=2; Product distribution / selectivity;