(S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

Base Information

• Chemical Name: (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid
• CAS No.: 119771-23-2
• Molecular Formula: C₁₄H₂₀BNO₆
• Molecular Weight: 309.127
• Mol file: 119771-23-2.mol

Synonyms:N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine

Chemical Property of (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

Chemical Property:

• PKA: 3.85±0.10(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(S)-3-(4-Boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid ≥97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

There total 6 articles about (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.26%

boric acid tributyl ester (688-74-4) + N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) → N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine (119771-23-2)

Guidance literature:

With 1,5-bis(methylamino)-3-oxapentane; tert-butylmagnesium chloride; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 30 ℃; for 22.5h; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) + p-borono-L-phenylalanine (76410-58-7) → N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine (119771-23-2)

Guidance literature:

With sodium carbonate; In water; acetone; at 20 ℃; for 24h;

DOI:10.1002/anie.201406221

Reference yield:

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate (220587-29-1,335030-24-5) → (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate (216439-76-8) + N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine (119771-23-2)

Guidance literature:

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate; With lithium hydroxide; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In tert-butyl methyl ether; water; pH=~ 4.5;

upstream raw materials:

di-tert-butyl dicarbonate

p-borono-L-phenylalanine

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

water

Downstream raw materials:

Nα-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-N-pentyl-L-phenylalaninamide

(2S)-2-(t-butoxycarbonylamino)-3-[4-(1-methyluracil-3-yl)phenyl] propionic acid

(S)-3-[4-(2-amino-6-chloropyrimidin-4-yl)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 119771-23-2 (S)-3-(4-boronophenyl)-2-((tert-butoxycarbonyl)amino)propanoicacid

Send

Send

Metric Ton KG G Pound L ML

Send

Send