3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

Base Information

Chemical Name:3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole
CAS No.:147144-92-1
Molecular Formula:C₂₇H₂₈BrNO
Molecular Weight:462.429
Hs Code.:

3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1<i>H</i>-benzo[<i>e</i>]indole

Synonyms:3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

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Chemical Property of 3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

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Technology Process of 3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

There total 4 articles about 3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 100-44-7
benzyl chloride

: 147201-38-5
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

: 147144-92-1
3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1021/jo960185l

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 147144-92-1
3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / toluene / 19 h / Heating

2: 62 percent / lithium aluminum hydride / tetrahydrofuran / -78 - 20 °C

3: 83 percent / KOH / dimethylsulfoxide / 1 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dimethyl sulfoxide; toluene; 1: Condensation / 2: Reduction / 3: Etherification;
DOI:10.1021/jo960185l

Reference yield:

: (8-bromo-2-oxo-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid ethyl ester

: 147144-92-1
3-(2-benzyloxy-1-phenyl-ethyl)-9-bromo-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / toluene / 19 h / Heating

2: 62 percent / lithium aluminum hydride / tetrahydrofuran / -78 - 20 °C

3: 83 percent / KOH / dimethylsulfoxide / 1 h / 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; dimethyl sulfoxide; toluene; 1: Condensation / 2: Reduction / 3: Etherification;
DOI:10.1021/jo960185l