5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1426960-44-2
Molecular Formula:C₃₃H₂₅F₂N₃O₅S
Molecular Weight:613.641
Hs Code.:

Synonyms:5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 16 articles about 5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1427034-44-3
2-chloro-11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

: 1426960-44-2
5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate tribasic trihydrate; XPhos; In water; at 110 ℃; for 12h;

Reference yield:

: 60633-25-2
2-bromo-4-chloroanisole

: 1426960-44-2
5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 6 h / 80 °C

2: potassium carbonate / methanol / 1 h / 25 °C

3: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / 12 h / 110 °C

4: boron tribromide / dichloromethane / 13 h / -78 - 25 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

6: XPhos; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 12 h / 110 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium phosphate tribasic trihydrate; tetrabutyl ammonium fluoride; boron tribromide; potassium carbonate; triethylamine; XPhos; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1427034-43-2
4-chloro-2-(4-fluoro-1H-indol-2-yl)phenol

: 1426960-44-2
5-(11-fluoro-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: XPhos; potassium phosphate tribasic trihydrate / 1,4-dioxane; water / 12 h / 110 °C

With potassium phosphate tribasic trihydrate; potassium carbonate; XPhos; In 1,4-dioxane; water; N,N-dimethyl-formamide;