Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide
There total 9 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide; bis(pinacol)diborane;
With
potassium acetate;
In
1,4-dioxane;
at 20 ℃;
for 4h;
Inert atmosphere;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane;
at 130 ℃;
for 1.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 - 90 °C / Inert atmosphere
2.1: potassium acetate / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere
2.2: 1.5 h / 130 °C / Inert atmosphere
With
potassium acetate; potassium carbonate; potassium iodide;
In
1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 0 - 20 °C
2.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 100 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C
4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 - 90 °C / Inert atmosphere
5.1: potassium acetate / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere
5.2: 1.5 h / 130 °C / Inert atmosphere
With
pyridine; lithium hydroxide monohydrate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
