2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide
CAS No.:1333340-17-2
Molecular Formula:C₂₄H₂₈BFN₂O₆S
Molecular Weight:502.372
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

There total 9 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1333225-20-9
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide

: 73183-34-3
bis(pinacol)diborane

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

Guidance literature:: 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide; bis(pinacol)diborane; With potassium acetate; In 1,4-dioxane; at 20 ℃; for 4h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 130 ℃; for 1.5h; Inert atmosphere;

Reference yield:

5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide: 1333244-33-9
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 - 90 °C / Inert atmosphere

2.1: potassium acetate / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 130 °C / Inert atmosphere

With potassium acetate; potassium carbonate; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1333340-15-0
ethyl 6-amino-5-bromo-2-(4-fluorophenyl)benzofuran-3-carboxylate

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 3 h / 100 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 80 - 90 °C / Inert atmosphere

5.1: potassium acetate / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

5.2: 1.5 h / 130 °C / Inert atmosphere

With pyridine; lithium hydroxide monohydrate; water; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;