N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

Base Information

• Chemical Name: N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide
• CAS No.: 96897-88-0
• Molecular Formula: C₁₆H₂₃IN₂O₃
• Molecular Weight: 418.275
• Mol file: 96897-88-0.mol

Synonyms:N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

Chemical Property of N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

There total 2 articles about N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(S)-2-(Aminomethyl)-1-ethylpyrrolidine (22795-99-9) + 3-iodo-2,6-dimethoxybenzoyl chloride → N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide (96897-88-0)

Guidance literature:

In chloroform; at 25 ℃; for 0.5h;

DOI:10.1021/jm00147a025

Reference yield:

3-iodo-2,6-dimethoxybenzoic acid (90347-70-9) → N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide (96897-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, DMF / toluene / 1 h / 65 °C

2: 55 percent / CHCl₃ / 0.5 h / 25 °C

With thionyl chloride; N,N-dimethyl-formamide; In chloroform; toluene;

DOI:10.1021/jm00147a025

Reference yield: 73.0%

N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide (96897-88-0) → [123I]-IBZM (84226-06-2,130383-75-4) + 5-Iodo-BZM (132448-74-9)

Guidance literature:

With hydrogenchloride; boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm00147a025

upstream raw materials:

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

3-iodo-2,6-dimethoxybenzoic acid

Downstream raw materials:

[123I]-IBZM

5-Iodo-BZM