5-Iodo-BZM

Base Information

• Chemical Name: 5-Iodo-BZM
• CAS No.: 132448-74-9
• Molecular Formula: C₁₅H₂₁IN₂O₃
• Molecular Weight: 404.248
• Mol file: 132448-74-9.mol

Synonyms:5-Iodo-BZM

Chemical Property of 5-Iodo-BZM

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Iodo-BZM

There total 7 articles about 5-Iodo-BZM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide (96897-88-0) → [123I]-IBZM (84226-06-2,130383-75-4) + 5-Iodo-BZM (132448-74-9)

Guidance literature:

With hydrogenchloride; boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/jm00147a025

Reference yield: 42.0%

(S)-2-(Aminomethyl)-1-ethylpyrrolidine (22795-99-9) + 6-hydroxy-3-iodo-2-methoxybenzoic acid (641616-55-9) → 5-Iodo-BZM (132448-74-9)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2003.08.063

Reference yield:

methyl 2,6-dihydroxybenzoate (2150-45-0) → 5-Iodo-BZM (132448-74-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ICl / CCl₄ / 48 h / 20 °C

1.2: imidazole / CH₂Cl₂ / 5 h / 20 °C

2.1: 72 percent / KHCO₃ / acetone / 24 h / Heating

3.1: 95 percent / Bu₄NF / tetrahydrofuran / 2 h / 20 °C

4.1: 74 percent / KOH / dioxane

5.1: 42 percent / dicyclohexylcarbodiimide; 1-hydroxy-benzotriazole hydrate / CH₂Cl₂ / 18 h / 20 °C

With potassium hydroxide; tetrabutyl ammonium fluoride; Iodine monochloride; potassium hydrogencarbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; acetone;

DOI:10.1016/j.bmcl.2003.08.063

upstream raw materials:

N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide

(S)-2-(Aminomethyl)-1-ethylpyrrolidine

6-hydroxy-3-iodo-2-methoxybenzoic acid

methyl 2,6-dihydroxybenzoate