6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate

Base Information

• Chemical Name: 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate
• CAS No.: 912848-80-7
• Molecular Formula: CH₄O₃S*C₁₆H₁₈N₂O₂
• Molecular Weight: 366.438
• Mol file: 912848-80-7.mol

Synonyms:6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate

Chemical Property of 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate

There total 5 articles about 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one (727993-68-2) + methanesulfonic acid (75-75-2,98527-29-8) → 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate (912848-80-7)

Guidance literature:

In 2,4-dimethylpentan-3-one; at 20 - 30 ℃; for 0.333333 - 0.416667h;

Reference yield:

4-((2-methyl-4-(methyloxy)phenyl)amino)butanenitrile (786700-82-1) → 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate (912848-80-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water / 4 h / 20 - 85 °C

2: 12 - 14 h / Heating / reflux

3: potassium tert-butylate / tetrahydrofuran / 5.17 - 5.33 h / Heating / reflux

4: 2,4-dimethylpentan-3-one / 0.33 - 0.42 h / 20 - 30 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; 2,4-dimethylpentan-3-one;

Reference yield:

1-[2-methyl-4-(methyloxy)phenyl]-2-pyrrolidinimine (786700-83-2) → 6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one methanesulfonate (912848-80-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 12 - 14 h / Heating / reflux

2: potassium tert-butylate / tetrahydrofuran / 5.17 - 5.33 h / Heating / reflux

3: 2,4-dimethylpentan-3-one / 0.33 - 0.42 h / 20 - 30 °C

With potassium tert-butylate; In tetrahydrofuran; 2,4-dimethylpentan-3-one;

upstream raw materials:

6-methyl-1-[2-methyl-4-(methyloxy)phenyl]-1,2,3,7-tetrahydro-4H-pyrrolo[2,3-b]pyridin-4-one

methanesulfonic acid

4-((2-methyl-4-(methyloxy)phenyl)amino)butanenitrile

1-[2-methyl-4-(methyloxy)phenyl]-2-pyrrolidinimine