Technology Process of 4-(2-benzyloxy-phenyl)-4-(tert-butyldimethylsilanyloxy)-1-(1,4,5,6,8-pentamethoxy-naphthalen-2-yl)-butan-2-one
There total 4 articles about 4-(2-benzyloxy-phenyl)-4-(tert-butyldimethylsilanyloxy)-1-(1,4,5,6,8-pentamethoxy-naphthalen-2-yl)-butan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere
2: water; hydrogen; boric acid / tetrahydrofuran; methanol / 13 h
3: triethylamine / dichloromethane / 1.4 h
With
water; hydrogen; boric acid; phenyl isocyanate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; phenyl isocyanate; benzene;
DOI:10.1021/jo200398v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; hydrogen; boric acid / tetrahydrofuran; methanol / 13 h
2: triethylamine / dichloromethane / 1.4 h
With
water; hydrogen; boric acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo200398v
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: water; trichlorophosphate / chloroform
2.1: ammonium acetate / 21.5 h / 120 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere
4.1: water; hydrogen; boric acid / tetrahydrofuran; methanol / 13 h
5.1: triethylamine / dichloromethane / 1.4 h
With
ammonium acetate; water; hydrogen; boric acid; phenyl isocyanate; triethylamine; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; phenyl isocyanate; benzene;
1.1: Vilsmeier formylation / 2.1: Henry reaction;
DOI:10.1021/jo200398v
