Technology Process of 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole
There total 3 articles about 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phenyl isocyanate; triethylamine;
In
phenyl isocyanate; benzene;
at 70 - 80 ℃;
for 44h;
Inert atmosphere;
DOI:10.1021/jo200398v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: water; trichlorophosphate / chloroform
2.1: ammonium acetate / 21.5 h / 120 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere
With
ammonium acetate; water; phenyl isocyanate; triethylamine; trichlorophosphate;
In
chloroform; phenyl isocyanate; benzene;
1.1: Vilsmeier formylation / 2.1: Henry reaction;
DOI:10.1021/jo200398v
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ammonium acetate / 21.5 h / 120 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere
With
ammonium acetate; phenyl isocyanate; triethylamine;
In
phenyl isocyanate; benzene;
1.1: Henry reaction;
DOI:10.1021/jo200398v
