5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Base Information

Chemical Name:5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole
CAS No.:1315340-92-1
Molecular Formula:C₃₂H₃₃NO₇
Molecular Weight:543.617
Hs Code.:

Synonyms:5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

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Chemical Property of 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

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Technology Process of 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

There total 3 articles about 5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1315340-90-9
1,2,4,5,8-pentamethoxy-6-(2-nitro-ethyl)-naphthalene

: 67191-36-0
1-(benzyloxy)-2-ethenylbenzene

: 1315340-92-1
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: With phenyl isocyanate; triethylamine; In phenyl isocyanate; benzene; at 70 - 80 ℃; for 44h; Inert atmosphere;
DOI:10.1021/jo200398v

Reference yield:

: 122182-21-2
1,2,4,5,8-pentamethoxynaphthalene

: 1315340-92-1
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; trichlorophosphate / chloroform

2.1: ammonium acetate / 21.5 h / 120 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere

With ammonium acetate; water; phenyl isocyanate; triethylamine; trichlorophosphate; In chloroform; phenyl isocyanate; benzene; 1.1: Vilsmeier formylation / 2.1: Henry reaction;
DOI:10.1021/jo200398v

Reference yield:

: 114263-49-9
1,4,5,6,8-pentamethoxynaphthalene-2-carbaldehyde

: 1315340-92-1
5-(2-benzyloxy-phenyl)-3-(1,4,5,6,8-pentamethoxynaphthalen-2-ylmethyl)-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / 21.5 h / 120 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: phenyl isocyanate; triethylamine / phenyl isocyanate; benzene / 44 h / 70 - 80 °C / Inert atmosphere

With ammonium acetate; phenyl isocyanate; triethylamine; In phenyl isocyanate; benzene; 1.1: Henry reaction;
DOI:10.1021/jo200398v